摘要:
蛋白质,DNA和糖分子并称为生命三大物质,糖类及含糖分子在药物领域有着重要的地位。但是目前制约糖类药物发展的一个重要因素是糖分子的合成,不像蛋白质和DNA可以通过模板高效合成,糖类分子的合成具有高度的特异性,无法通过模板方式进行。目前糖类药物的合成主要有化学合成和酶促合成两种方式。相比于化学法,酶法具有高效,专一,条件温和,环保等一系列优势,是糖类药物合成的趋势。本公司在传统酶促合成的基础上,开发出了一套基于体外合成生物学的技术平台,运用一锅多酶法等合成策略,探索了若干糖类药物的高效合成。
讲座视频:
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